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Charak Samhita

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विमार्गस्था ह्ययुक्ता वा रोगैः स्वस्थानकर्मजैः । शरीरं पीडयन्त्येते प्राणानाशु हरन्ति च ॥१२॥

Role of vata/vayu in causing diseases: When dislodged or impaired, dosha harm the body by diseases according to their respective site and function, and may even lead to instantaneous death.

english translation