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Charak Samhita

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पक्वाशयस्थाः सर्वेऽपि बस्तिभिर्मूलनिर्जयात् । शक्या न त्वाममेदोभ्यां स्तब्धा जङ्घोरुसंस्थिता ॥२३॥

When lodged in pakvashaya, all the three dosha could be fully removed by enema therapy. But in urusthambha since pathognomonic doshas are stagnant due to amatva (metabolic defect) and obstructed by fat,

english translation