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Charak Samhita

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पूतिगन्धान् विवर्णांश्च बहुस्रावान्महारुजः । व्रणानशुद्धान् विज्ञाय शोधनैः समुपाचरेत् ॥८३॥

[Vrana shodhana (local purification of ulcers)] Wounds with foul odor, abnormal color, profuse discharge and intense pain should be known as dushta vrana (unclean) and as such wounds should be treated with cleansing agents.

english translation