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Charak Samhita

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परिस्रावाच्च गन्धाच्च दोषाच्चोपद्रवैः सह । व्रणानां बहुदोषाणां कृच्छ्रत्वं चोपजायते ॥३५॥

Ulcers having much impurity become difficult to be cured due to presence of excessive discharges, odors, defects and complications.

english translation

Chapter 25

Verse 36