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Charak Samhita

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कार्याकार्यं सुखं दुःखं लोके यच्च हिताहितम् । यदवस्थो न जानाति कोऽवस्थां तां व्रजेद्बुधः ॥५०॥

He proceeds to a stage where the identification of right or wrong, happiness or sorrow, desirable or undesirable in the universe is not recognizable.

english translation