Charak Samhita
कार्याकार्यं सुखं दुःखं लोके यच्च हिताहितम् । यदवस्थो न जानाति कोऽवस्थां तां व्रजेद्बुधः ॥५०॥
He proceeds to a stage where the identification of right or wrong, happiness or sorrow, desirable or undesirable in the universe is not recognizable.
english translation
kAryAkAryaM sukhaM duHkhaM loke yacca hitAhitam । yadavastho na jAnAti ko'vasthAM tAM vrajedbudhaH ॥50॥
hk transliteration by Sanscript