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Charak Samhita

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भेषजमेवं कल्प्यं भिषग्विदाऽऽलक्ष्य सर्वदा सर्वम् । स्थानं जयेद्धि पूर्वं स्थानस्थस्याविरुद्धं च ॥६४॥

If the visha is located in rakta sthana (site of rakta dhatu), or if the patient is afflicted with dooshivisha then the patient should be administered with siravyadhana (bloodletting) and Panchakarma (five types of elimination therapies).

english translation