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Charak Samhita

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दोषे कोष्ठगते भूय एतत् कुर्याच्चिकित्सितम् शाखादुष्टे तु रुधिरे रक्तमेवादितो हरेत् ॥६८॥

When the morbid dosha are situated in kostha (internally), these measures should be administered. [Formulations for dosha situated in shakha and modes of blood letting] If dosha in shakha (body elements) vitiate the blood then raktamokshana should be administered at first.

english translation