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Charak Samhita

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यस्य सर्वाणि लिङ्गानि बलवद्यस्यकारणम् । यस्य चोपद्रवाः कष्टा मर्मगो यश्च हन्ति सः ॥२८॥

[Bad prognostic features] Visarpa manifesting with all signs and symptoms, having strong etiological factors, which is associated with formidable complications and that situates as well as affects vital parts, proves fatal.

english translation