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Charak Samhita

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तस्मात् साधारणावेतौ मतौ परमदुर्जयौ । मिथ्योपचरितौ क्रुद्धौ हत आशीविषाविव ॥९॥

Hence generally they are extremely difficult to treat. After getting afflicted with this disease, if one indulges in unwholesome regimens, then disease gets aggravated and results in death just as from fatal snake venom.

english translation