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Charak Samhita

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मेदसस्तानि पूर्यन्ते स्नेहो मज्जा ततः स्मृतः। तस्मान्मज्ज्ञस्तु यः स्नेहः शुक्रं सञ्जायते ततः॥३२॥

[Formation of shukra dhatu] The sneha (fatty) portion of majja produces shukra. The porosity in the asthi is produced because of the factors such as vata and akasha.

english translation