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Charak Samhita

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तेजो रसानां सर्वेषां मनुजानां यदुच्यते। पित्तोष्मणः स रागेण रसो रक्तत्वमृच्छति॥२८॥

undergoes transformation by the ushma (heat) of pitta and gets converted into the red colored tissue known as rakta

english translation