Charak Samhita

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मन्देऽग्नौ मलिनैर्भुक्तैरपाकाद्दोषसञ्चयः| प्राणाग्न्यपानान् सन्दूष्य मार्गान्रुद्ध्वाऽधरोत्तरान् ||१०||

In the state of impaired jatharagni consumption of unhealthy foods further leads to indigestion and eventually causes accumulation of morbid substances. Thus formed morbidity afflicts the functioning of prana vata, agni as well as apana vata which in turn obliterates the channels tending upwards and downwards.

english translation

mande'gnau malinairbhuktairapAkAddoSasaJcayaH| prANAgnyapAnAn sandUSya mArgAnruddhvA'dharottarAn ||10||

hk transliteration by Sanscript