Charak Samhita

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अतिप्रवृत्तिः सङ्गो वा सिराणां ग्रन्थयोऽपि वा। विमार्गगमनं चापि स्रोतसां दुष्टिलक्षणम् ॥२४॥

[Four features of srotas morbidity] Increased flow or obstruction or formation of nodules and flow of bodily fluids or contents in the wrong or opposite direction are the features of morbidity of srotas.

english translation