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Charak Samhita

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पञ्च चापि कषायाणां शतान्युक्तानि भागशः। लक्षणार्थं, प्रमाणं हि विस्तरस्य न विद्यते ॥२६॥

Further, fifty subgroups of medicines have also been mentioned along with the five hundred medicines as ingredients for the sake of definition.

english translation