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Charak Samhita

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क्वचिदेको रसः कल्प्यः संयुक्ताश्च रसाः क्वचित्। दोषौषधादीन् सञ्चिन्त्य भिषजा सिद्धिमिच्छता ॥२५॥

The physician, desirous of success, should administer rasas, in pure forms or in combinations based on dosha, drugs etc.

english translation