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Charak Samhita

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कालजस्त्वेव पुरुषः कालजास्तस्य चामयाः। जगत् कालवशं सर्वं कालः सर्वत्र कारणम् ॥२५॥

Human beings and their diseases are caused by time (kala) because the whole universe is under control of kala. Kala is the origin of all.

english translation