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Charak Samhita

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देहाग्निदोषभैषज्यमात्राकालानुवर्तिना। कार्यमत्वरमाणेन भेषजं चिरदुर्बले ॥३२॥

Some of the critical factors for deciding a course of treatment of emaciation in chronic patients include: body constitution, power of digestion, predominant dosha, form of medicine, dose, and season and time of administration (of the therapy).

english translation