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Charak Samhita

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लक्षणं चाकृतानां स्यात् षण्णामेषां समासतः। तदौषधानां धातूनामशमो वृद्धिरेव च ॥४१॥

The signs and symptoms of all these six therapies, if inadequately administered, leave the dosha unpacified. Rather, they get aggravated.

english translation