Charak Samhita

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नास्तिकस्यास्ति नैवात्मा यदृच्छोपहतात्मनः| पातकेभ्यः परं चैतत् पातकं नास्तिकग्रहः ||१५||

sanskrit

For these people, there is no existence of God, sages, siddhas, and therefore, they do not believe in concepts such as karma (action) and karmaphala (results of the action). Thus, nihilism constitutes the worst sin in this world.

english translation

nAstikasyAsti naivAtmA yadRcchopahatAtmanaH| pAtakebhyaH paraM caitat pAtakaM nAstikagrahaH ||15||

hk transliteration