Charak Samhita

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गम्भीरंबहुधातुस्थंमर्मसन्धिसमाश्रितम्। नित्यानुशायिनंरोगंदीर्घकालमवस्थितम् ॥१८॥

3. The disease involves a number of dhatus 4. It affects the vital organs and joints 5. It affects the patient continuously for a long time (chronic), and 6. The disease is caused by the vitiation of the two doshas.

english translation

gambhIraMbahudhAtusthaMmarmasandhisamAzritam। nityAnuzAyinaMrogaMdIrghakAlamavasthitam ॥18॥

hk transliteration by Sanscript