Charak Samhita
गम्भीरंबहुधातुस्थंमर्मसन्धिसमाश्रितम्। नित्यानुशायिनंरोगंदीर्घकालमवस्थितम् ॥१८॥
3. The disease involves a number of dhatus 4. It affects the vital organs and joints 5. It affects the patient continuously for a long time (chronic), and 6. The disease is caused by the vitiation of the two doshas.
english translation
gambhIraMbahudhAtusthaMmarmasandhisamAzritam। nityAnuzAyinaMrogaMdIrghakAlamavasthitam ॥18॥
hk transliteration by Sanscript