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Charak Samhita

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अल्पं तु बहुदोषस्य दोषमुत्क्लिश्य भेषजम्। अल्पाल्पं स्रावयेत् कण्डूं शोफं कुष्ठानि गौरवम्॥६८॥

[Complication of paristrava (discharge) and its management] In the patients with excessively vitiated doshas, when only a small dose of medicine is given, the dosha get aggravated and discharged out in little quantity frequently.

english translation