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Charak Samhita

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उत्पद्येत हि साऽवस्था देशकालबलं प्रति। यस्यां कार्यमकार्यं स्यात् कर्म कार्यं च वर्जितम्॥२६॥

time and strength of the patient in which the prescribed therapy may be ineffective and the prohibited therapy may be applicable such as emesis is prescribed in certain stage of vomiting, heart-disease and gulma (abdominal lump) though it is generally contra-indicated.

english translation