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Charak Samhita

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मिथ्योपचाराच्च न तं विकारं शान्तिं नयेत् पथ्यमपि प्रयुक्तम्। तत्र श्लोकः- प्रश्नानिमान् द्वादश पञ्चकर्माण्युद्दिश्य सिद्धाविह कल्पनायाम्॥६०॥

in inappropriate time or in wrong manner then it fails to cure diseases. [Summary] To sum up, Lord Atreya the foremost among the sages described the successful administration of Panchakarma for the well being of the people in the form of answer to the twelve queries.

english translation