Charak Samhita

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धीधृतिस्मृतिविभ्रंशः सम्प्राप्तिः कालकर्मणाम्। असात्म्यार्थागमश्चेति ज्ञातव्या दुःखहेतवः ॥९८॥

॥ Basic causes of miseries in life॥ Impairment of intellect (grasping and keeping power), dhriti (controlling power) and memory (recalling power), ageing/advent of maturity, deeds and unwholesome contact with objects of senses could be counted as factors responsible for causing miseries.

english translation

dhIdhRtismRtivibhraMzaH samprAptiH kAlakarmaNAm। asAtmyArthAgamazceti jJAtavyA duHkhahetavaH ॥98॥

hk transliteration by Sanscript