अकालादेशसञ्चारौ मैत्री सङ्क्लिष्टकर्मभिः| इन्द्रियोपक्रमोक्तस्य सद्वृत्तस्य च वर्जनम् ||१०६||
enjoyment of harmful objects, resorting to the factors that are responsible for the causation of madness, walking and travelling at improper time and places, friendship with persons of bad character,
ईर्ष्यामानभयक्रोधलोभमोहमदभ्रमाः| तज्जं वा कर्म यत् क्लिष्टं क्लिष्टं यद्देहकर्म च ||१०७||
avoidance of sadvritta (noble code of conduct) described in Indriyopakramaniya Adhyaya (Sutra Sthana 8th chapter) or harboring malice, vanity, fear, anger, greed, ignorance,
intoxication and bewilderment or bad actions arising out of any of them, and/or physical evil acts arising out of rajas and tamas constitute prajnaparadha, the root cause of several diseases told by learned seers of Ayurveda.
बुद्ध्या विषमविज्ञानं विषमं च प्रवर्तनम्| प्रज्ञापराधं जानीयान्मनसो गोचरं हि तत् ||१०९||
Understanding the subjects in improper way due to the impairment of intellect and, at the same time, executing this improper knowledge in the wrong way is also termed as prajnaparadha which makes improper cognition of manasa, indriya with their objects and subjects.
निर्दिष्टा कालसम्प्राप्तिर्व्याधीनां व्याधिसङ्ग्रहे| चयप्रकोपप्रशमाः पित्तादीनां यथा पुरा ||११०||
[Importance of Kala (time factor)] Ailments due to the advent of the season are already described in Sutra 17:114. It has been explained there, how pitta and other doshas get accumulated, aggravated and alleviated (depending on seasonal variation).