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Charak Samhita

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बहुदोषः संशोध्यः कुष्ठी बहुशोऽनुरक्षता प्राणान्। दोषे ह्यतिमात्रहृते वायुर्हन्यादबलमाशु ॥४१॥

Patients with excessive vitiated dosha should be given shodhana therapy repeatedly; taking care about their prana (strength). Excessive elimination of dosha may increase vata dosha which may bring about weakness and in rare condition endanger the life of patient.

english translation