Charak Samhita

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जातः प्रमेही मधुमेहिनो वा न साध्य उक्तः स हि बीजदोषात्| ये चापि केचित् कुलजा विकारा भवन्ति तांश्च प्रवदन्त्यसाध्यान् ||५७||

sanskrit

[In-curability of hereditary diseases] Patients who suffer from prameha since birth (congenital) and those who are borne of prameha parents (hereditary) are not curable because of the morbidity in their bija (genes). Similarly, other hereditary (kulaja/familial) ailments are considered as incurable.

english translation

jAtaH pramehI madhumehino vA na sAdhya uktaH sa hi bIjadoSAt| ye cApi kecit kulajA vikArA bhavanti tAMzca pravadantyasAdhyAn ||57||

hk transliteration