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Charak Samhita

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महारुजं दाहपरीतमश्मवद्घनोन्नतं शीघ्रविदाहि दारुणम्। मनःशरीराग्निबलापहारिणं त्रिदोषजं गुल्ममसाध्यमादिशेत् ॥१७॥

[Signs and symptoms of tri-doshaja gulma] The symptoms of tri-dosha gulma include agonizing pain and excessive burning sensation, elevated mass, stony hard and quick to mutilate. It is a very serious condition and leads to diminution of strength of body, mind and digestion. It is incurable

english translation