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Charak Samhita

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ज्वरिभ्यो बहुदोषेभ्य ऊर्ध्वं चाधश्च बुद्धिमान्। दद्यात् संशोधनं काले कल्पे यदुपदेक्ष्यते ॥२२७॥

[Formulations used in purification therapies] Elimination therapies (of doshas), both in upward and downward routes should be administered at appropriate time, to a patient suffering from jwara, having more aggravated doshas. Details of these methods and the formulations used for them will be discussed in the Kalpa Sthana.

english translation