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Charak Samhita

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हस्ते पादे मुखे नाभ्यां गुदे वृषणयोस्तथा। शोथो हृत्पार्श्वशूलं च यस्यासाध्योऽर्शसो हि सः॥२६॥

[Symptoms of incurable arsha] If the patient of hemorrhoids develops edema in upper and lower extremities, face, umbilicus, anus and scrotum, and if he suffers from pain in the cardiac region and lateral parts of chest, then such types of patients became incurable.

english translation