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Charak Samhita

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स्वादुरम्लादिभिर्योगं शेषैरम्लादयः पृथक्। यान्ति पञ्चदशैतानि द्रव्याणि द्विरसानि तु ॥१५॥

Combination of two rasas such as sweet with sour etc. and sour with others, lead to creation of fifteen combinations.

english translation