Charak Samhita

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मात्राकालक्रियाभूमिदेहदोषगुणान्तरम् । प्राप्य तत्तद्धि दृश्यन्ते ते ते भावास्तथा तथा ॥४६॥

This is, however, not a cardinal rule, and food articles and drugs do have a variety of effects depending on the dosage, time, mode of preparation, geographical location, the body constitution of the patient, and dosha.

english translation

mAtrAkAlakriyAbhUmidehadoSaguNAntaram । prApya tattaddhi dRzyante te te bhAvAstathA tathA ॥46॥

hk transliteration by Sanscript